METHOD FOR DETERMINING RISK OF AMYOTROPHIC LATERAL SCLEROSIS
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United States of America Patent
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app pub date -
Jan 3, 2014
filing date -
Jun 20, 2011
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Abandoned
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Abstract
The present invention provides a method of determining a risk for amyotrophic lateral sclerosis (ALS) in a subject, comprising the following steps: (1) measuring a concentration of an autoantibody against HMGB1 in a biological sample from the subject; and (2) comparing the measured concentration of the autoantibody against HMGB1 with a control value for autoantibody against HMGB1; wherein a difference between the measured concentration of the autoantibody against HMGB1 from the biological sample and the control value for autoantibody against HMGB1 is indicative of the risk of ALS in the subject.
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