ANTAGONISTS OF TRPV1 RECEPTOR
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United States of America Patent
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Issued Date -
May 1, 2014
app pub date -
Apr 26, 2012
filing date -
Apr 26, 2011
priority date (Note) -
Abandoned
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Abstract
TRPV1 antagonists and associated methods are provided. A TRPV1 channel antagonist can have the structure: Formula (I) wherein R1 can be —CH3, —(CH2)X(CH)YCH3 where x+y=1-20, an aromatic, a (CH2)n aromatic where n can be less than or equal to 6, a lipid, or a linker, and wherein R2 can be either Formula (II) or Formula (III) Additionally, R3 can be —O—R4 or —NH—R4 and R4 can be —H, —CH3, an ester, a cyclic ester, or an amide.
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