CORTICOSTEROID PARTICLES AND METHOD OF PRODUCTION

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United States of America Patent

APP PUB NO 20140120165A1
SERIAL NO

14044456

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Abstract

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A new particle morphology of glucocorticosteroids is described. The forms have a particle morphology that is particularly well suited for use in an inhaled corticosteroid drug suspension formulation for delivery from a next generation nebulizer device. Use of the new glucocorticosteroid particles enables enhanced drug delivery efficiency and increased residence time of the delivered drug in the lungs. New methods for producing glucocorticosteroid particles having these specific particle morphologies are also described. The methods provide a simplified, reproducible and scalable particle formation process that can produce glucocorticosteroid particles having a narrow particle size and shape distribution, a low surface energy, a low aspect ratio, uniform particle morphology and a reduced specific surface area.

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Patent Owner(s)

Patent OwnerAddress
MAP PHARMACEUTICALS INC2525 DUPONT DRIVE IRVINE CA 92612

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Watanabe, Wiwik Mountain View, US 15 151
Wu, Libo Mountain View, US 33 164
Zhang, Jian Mountain View, US 1504 17611

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