INHIBITORS OF NITRIC OXIDE SYNTHASE
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United States of America Patent
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Issued Date -
Apr 24, 2014
app pub date -
Jul 26, 2013
filing date -
Nov 25, 1997
priority date (Note) -
Abandoned
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Abstract
The current invention discloses novel methods for the inhibition of inducible nitric oxide synthesis (iNOS) and the production of NO. Methods of inhibiting the induction of proinflammatory cytokines are also described. Methods of treating various disease states, such as X-linked adrenoleukodystrophy, multiple sclerosis, Alzheimer's and septic shock using inhibitors of iNOS and cytokine induction are disclosed. The inhibitors include the exemplary compounds lovastatin, a sodium salt of phenylacetic acid (NaPA), FPT inhibitor II, N-acetyl cysteine (NAC), and cAMP.
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