PARENTERAL FORMULATION FOR EPOTHILONE ANALOGS

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United States of America Patent

APP PUB NO 20140107169A1
SERIAL NO

14134172

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A process for formulating certain epothilone analogs for parenteral administration is disclosed wherein the analog is dissolved in a mixture of at least 50% by volume tertiary-butanol in water, the mixture is lyophilized, the resulting lyophilized product is packaged in one vial with a sufficient amount of solvent comprising anhydrous ethanol and a suitable nonionic surfactant in a second vial. All steps are carried out with protection from light. In use, the contents of the second or diluent vial are added to the lyophilized product and mixed to constitute the epothilone analog and the resulting solution is diluted with a suitable diluent to produce a solution for intravenous injection containing the epothilone analog in a concentration of from about 0.1 mg/mL to about 0.9 mg/mL. A preferred surfactant is polyethoxylated castor oil and a preferred diluent is Lactated Ringer's Injection.

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Patent Owner(s)

Patent OwnerAddress
R-PHARM US OPERATING LLC100 OVERLOOK CENTER 2ND FLOOR PRINCETON NJ 08540

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bandyopadhyay, Rebanta Portage, US 21 346
Malloy, Timothy M Yardley, US 14 187
Panaggio, Andrea West Windsor, US 10 149
Raghavan, Krishnaswamy Srinivas Cranbury, US 13 146
Varia, Sailesh Amilal Princeton Junction, US 9 136

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