METHODS OF TREATING FIBROSING DISEASES BY INDUCTION OF IMMUNE TOLERANCE
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United States of America Patent
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Apr 17, 2014
app pub date -
Dec 13, 2013
filing date -
Nov 16, 2005
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Abstract
The present invention has demonstrated for the first time that orally administered type I collagen (CI) induced tolerance to CI in patients suffering from systemic sclerosis (SSc) and ameliorated clinical manifestations of the disease. Accordingly, the present invention provides methods of treating a fibrosing disease by oral administration of a tissue protein, for example, collagen, derived from the tissue undergoing fibrosis.
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