COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASES COMPRISING VERATRIC ACID AS EFFECTIVE COMPONENT
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United States of America Patent
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Issued Date -
Apr 10, 2014
app pub date -
Jun 27, 2013
filing date -
Oct 10, 2012
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Abandoned
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Abstract
There is provided a composition including a veratric acid for preventing or treating inflammatory diseases. The veratric acid of the present invention has an excellent effect of inhibiting production of nitric oxide, an excellent activity of inhibiting production of IL-1β as a pro-inflammatory cytokine, and an excellent effect of inhibiting phosphorylation of MAPK, NF-κB, GSK-3β, and c-Raf in a macrophage cell stimulated by a stimulation factor that causes an inflammatory reaction. Thus, it can be used for development of medicines for treating inflammatory diseases which can be caused by excessive inflammatory reactions. Further, the veratric acid of the present invention does not induce toxicity to cells and is stable in the body. Thus, it can be used as a material of a health functional food capable of preventing or improving inflammatory diseases.
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