IMMUNOGENIC COMPOSITIONS AND EXPRESSION SYSTEMS
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United States of America Patent
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app pub date -
Oct 7, 2011
filing date -
Oct 8, 2010
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Abstract
Immunogenic compositions and vaccines against Plasmodial infection comprising an Rh polypeptide or a fragment or variant thereof are disclosed. Also disclosed are Rh5 polypeptides or fragments or variants thereof capable of binding CD147 and conferring protection against infection and/or disease caused by multiple Plasmodial strains or Plasmodial species, inhibitors of the interaction between Rh5 and CD147 and methods for producing polypeptides in a mammalian expression system.
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