Complexation of Metal Ions with Polypeptides
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United States of America Patent
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Issued Date -
Mar 27, 2014
app pub date -
Mar 7, 2013
filing date -
Jun 23, 2005
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Abstract
Formulations and methods are provided for improving the stability upon exposure to aqueous media of polypeptides present in non-aqueous suspension vehicles. In particular aspects of the invention, formulations are provided that comprise a complex of a metal ion and a polypeptide suspended in a non-aqueous, biocompatible suspension vehicle. Aggregation of individual polypeptide molecules is reduced when aqueous media is introduced to such formulations, serving to stabilize the polypeptide.
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