SERINE BIOSYNTHESIS PATHWAY INHIBITION FOR TREATMENT OF CANCER
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United States of America Patent
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Issued Date -
Mar 27, 2014
app pub date -
Mar 30, 2012
filing date -
Mar 30, 2011
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Abandoned
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Abstract
In some aspects, the invention provides compounds and methods of use for treating tumors. In some aspects, the methods comprise administering a serine biosynthesis pathway inhibitor to a subject, wherein the subject has a tumor that overexpresses PHGDH In some embodiments, the tumor is an ER negative breast cancer. In some aspects, the invention provides an in vivo RNAi-based negative selection screen of use to identify drug targets for treatment of tumors.
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