TIGHT JUNCTIONS MODULATORS
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United States of America Patent
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Issued Date -
Mar 27, 2014
app pub date -
Mar 23, 2012
filing date -
Mar 31, 2011
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Abstract
The present invention relates to a new therapy targeted at the restoration or improvement of tight junction function. Aberrant TJ function, is characteristic of many chronic skin diseases. The inventors demonstrated that plant polyphenols or flavonoids and Cis-urocanic acid modulates tight junction structure and function in mammalian keratinocytes and provided tight junction modulators, pharmaceutical compositions and methods for preventing or treating impaired tight junction function in stratified mammalian epithelia.
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