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Country	kind	publication No.	Filing Date	Type	Sub-Type
GB	D0	GB201105411	Mar 31, 2011	Patent	Application
Type : Patent Sub-Type : Application
Patent application filed (unpublished application)		Tight junctions modulators		Jan 01, 1970
EP	A2	EP2691090	Mar 23, 2012	Patent	Application
Type : Patent Sub-Type : Application
APPLICATION PUBLISHED WITHOUT SEARCH REPORT		TIGHT JUNCTIONS MODULATORS		Feb 05, 2014
WO	A2	WO2012131341	Mar 23, 2012	Patent	Application
Type : Patent Sub-Type : Application
INTERNATIONAL APPLICATION PUBLISHED WITHOUT INTERNATIONAL SEARCH REPORT or INTERNATIONAL APPLICATION PUBLISHED WITH DECLARATION UNDER ARTICLE 17 (2) (A)		TIGHT JUNCTIONS MODULATORS		Oct 04, 2012

• 15 United States
• 10 France
• 8 Japan
• 7 China
• 5 Korea
• 2 Other

Patent Owner(s)

Patent Owner	Address
THE UNIVERSITY OF MANCHESTER	OXFORD ROAD MANCHESTER M13 9PL

International Classification(s)

• A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....

• 2012 Application Filing Year
• A61K Class
• 11964 Applications Filed
• 9694 Patents Issued To-Date
• 81.03 % Issued To-Date

Inventor(s)

Inventor Name	Address	# of filed Patents	Total Citations
Gibbs, Neil Kerslake	Manchester, GB	4	0
# of filed Patents : 4 Total Citations : 0
O'neill, Catherine Anne	Manchester, GB	2	2
# of filed Patents : 2 Total Citations : 2

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Patent Citation Ranking

• 0 Citation Count
• A61K Class

• 0 % this patent is cited more than
• 11 Age

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Maintenance Fees

Fee	Large entity fee	small entity fee	micro entity fee	due date
11.5 Year Payment	$7400.00	$3700.00	$1850.00	Sep 27, 2025

Fee	Large entity fee	small entity fee	micro entity fee
Surcharge - 11.5 year - Late payment within 6 months	$160.00	$80.00	$40.00
Surcharge after expiration - Late payment is unavoidable	$700.00	$350.00	$175.00
Surcharge after expiration - Late payment is unintentional	$1,640.00	$820.00	$410.00

Full Text

US Patent Application No: 2014/0086,977

TIGHT JUNCTIONS MODULATORS

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Abstract

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The present invention relates to a new therapy targeted at the restoration or improvement of tight junction function. Aberrant TJ function, is characteristic of many chronic skin diseases. The inventors demonstrated that plant polyphenols or flavonoids and Cis-urocanic acid modulates tight junction structure and function in mammalian keratinocytes and provided tight junction modulators, pharmaceutical compositions and methods for preventing or treating impaired tight junction function in stratified mammalian epithelia.

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Description

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