Histone Deacetylase Inhibitors for Enhancing Activity of Antifungal Agents
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United States of America Patent
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Issued Date -
Mar 20, 2014
app pub date -
Mar 14, 2013
filing date -
Sep 14, 2012
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Abstract
The present invention relates to compositions and methods to selectively treat fungal infection. More particularly, the invention relates to compounds, compositions thereof, and methods for selectively enhancing fungal sensitivity to antifungal compounds. The compositions of the invention are comprised of a combination of a histone deacetylase inhibitor, or an N-oxide, hydrate, solvate, pharmaceutically acceptable salt, agricultural formulation, prodrug or complex thereof, and an antifungal agent, the histone deacetylase inhibitor being a compound of Formula (I):
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