Pharmaceutical Formulations Including An Amine Compound
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United States of America Patent
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Issued Date -
Mar 20, 2014
app pub date -
Jan 31, 2012
filing date -
Feb 1, 2011
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Abandoned
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Abstract
The present invention relates to solid, semisolid, or liquid formulations comprising water soluble antioxidants that prevent or reduce formic acid and/or formyl species generation in the dosage form during the manufacturing process and/or during shelf-life storage. The formulations of the present invention prevent or reduce formation of N-formyl impurities (and gelatin crosslinking) during the manufacturing process and/or during shelf-life storage.
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