CHEMICALLY MODIFIED OLIGONUCLEOTIDES FOR USE IN MODULATING MICRO RNA AND USES THEREOF

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United States of America Patent

APP PUB NO 20140073684A1
SERIAL NO

14011387

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Abstract

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This invention relates generally to chemically modified oligonucleotides useful for modulating expression of microRNAs and pre-microRNAs. More particularly, the invention relates to single stranded chemically modified oligonucleotides for inhibiting microRNA and pre-microRNA expression and to methods of making and using the modified oligonucleotides. Also included in the invention are compositions and methods for silencing microRNAs in the central nervous system.

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Patent Owner(s)

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REGULUS THERAPEUTICS INC3545 JOHN HOPKINS COURT SUITE 210 SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Manoharan, Muthiah Weston, US 491 18658
Rajeev, Kallanthottathil G Wayland, US 260 8660
Stoffel, Markus Zurich, CH 25 544

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