Immunoglobulin Constructs Comprising Selective Pairing of the Light and Heavy Chains
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United States of America Patent
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Mar 13, 2014
app pub date -
Jul 23, 2013
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Jul 23, 2012
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Abstract
Disclosed herein is an isolated immunoglobulin construct comprising a first monomeric polypeptide comprising a first single chain Fv polypeptide connected to a first constant domain polypeptide; and a second monomeric polypeptide comprising a second single chain Fv polypeptide, connected to a second constant domain polypeptide; each said constant domain polypeptide comprising at least one each of a CL domain, a CH1 domain, a CH2 domain and a CH3 domain or fragments, variants or derivatives thereof; and wherein said first and second constant domain polypeptide form a Fc region.
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