ELECTROCHEMICAL REDUCTION OF DISULFIDE BONDS IN PROTEINACEOUS SUBSTANCES AND ELECTROCHEMICAL CELL FOR CARRYING OUT SUCH REDUCTION
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United States of America Patent
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Mar 13, 2014
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Sep 10, 2012
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Sep 10, 2012
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Abstract
A method of cleaving disulfide bonds is provided, which comprises: (a) introducing a liquid sample having disulfide bonds (e.g., proteins) into an electrochemical cell; and (b) subjecting the sample to a reducing potential to reduce the disulfide bonds, wherein the electrochemical cell comprises (i) a working electrode that contains titanium and (ii) an auxiliary electrode. An electrochemical flow cell for processing a sample fluid is also provided, which comprises: (a) a body comprising a flow path having inlet and an outlet; (b) a working electrode in fluid communication with the flow path; and (c) an auxiliary electrode; wherein the working electrode comprises at least 20 wt. % titanium in the form of elemental titanium, titanium-containing substances and/or titanium-containing alloys; and wherein the outlet is connected to an electrochemical detection (ECD) device, a NMR spectrometer or a mass spectrometer (MS) when the working electrode is a ruthenium-plated titanium electrode.
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