NOVEL LOWERED AFFINITY ANTIBODIES AND USES THEREFOR

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United States of America Patent

APP PUB NO 20140066600A1
SERIAL NO

13962113

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides novel, rationally designed lowered affinity antibodies for use in various in vivo and in vitro applications. The antibodies of the present invention have variable domains that have been designed to reduce or eliminate the antigen binding activity of the parental antibody without altering the overall 3 dimensional antibody structure. Using the antibodies of the present invention in various assays allows researchers to distinguish effects that result from specific antigen-antibody interactions from other, non-specific antibody effects.

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Patent Owner(s)

Patent OwnerAddress
AB BIOSCIENCES INC561 VIRGINIA ROAD BUILDING 4 SUITE 301 CONCORD MA 01742

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chang, Hsiu-Ching Lexington, US 10 21

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