Recombinant Beta-Glucosidase Variants for Production of Soluble Sugars from Cellulosic Biomass

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United States of America Patent

APP PUB NO 20140065678A1
SERIAL NO

14075728

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Abstract

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The invention relates to recombinant expression of a variant form of a fungal C1 strain β-glucosidase. The invention also relates to the generation of fermentable sugars from biomass and the production of biofuels by fermentation of the sugars using genetically modified organisms expressing the β-glucosidase variant. The invention provides methods for producing a fermentable sugar, such as glucose, from cellobiose by contacting cellobiose with a recombinant β-glucosidase variant protein, such as a variant protein secreted by a recombinant host cell into culture medium. Methods of the invention may be used for conversion of a biomass substrate to a fermentable sugar, and ultimately to ethanol or other biofuel.

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CODEXIS INCCALIFORNIA USA CALIFORNIA

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  • 2013 Application Filing Year
  • C12N Class
  • 5078 Applications Filed
  • 4006 Patents Issued To-Date
  • 78.89 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances20132014201520162017201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Andor, Attila Budapest, HU 15 76
Yang, Jie Foster City, US 566 3601
Zhang, Xiyun Fremont, US 141 584

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges9021960310944227951501 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7081 - 90100 +0100200300400500600700800900100011001200130014001500160017001800190020002100

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