Inhalable pharmaceutical compositions
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United States of America Patent
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Jul 17, 2018
Grant Date -
Mar 6, 2014
app pub date -
Feb 28, 2013
filing date -
Feb 28, 2012
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Abstract
Methods for making inhalable composite particles comprising a pharmaceutically-active agent, the method comprising: a) providing composite particles comprising a millable grinding matrix and a solid pharmaceutically-active agent, wherein the pharmaceutically-active agent has an median particle size on a volume average basis between 50 nm and 3 μm; and b) milling the composite particles in a mill without milling bodies for a time period sufficient to produce inhalable composite particles having a mass median aerodynamic diameter between 1 μm and 20 μm are described.
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