CONJUGATES OF ACYL HOMOSERINE LACTONE AND CATALASE A FROM PSEUDOMONAS AERUGINOSA
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United States of America Patent
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Issued Date -
Mar 6, 2014
app pub date -
Dec 23, 2011
filing date -
Dec 24, 2010
priority date (Note) -
Abandoned
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Abstract
The present invention is directed to an acyl homoserine lactone and catalase conjugate wherein the acyl homoserine lactone is N-3-(oxododecanoyl)-L-homoserine lactone (OdDHL) or butyryl L-homoserine lactone (BHL) and the catalase is a P. aeruginosa KatA protein or an antigenic portion thereof. The conjugate is used to treat P. aeruginosa infections by limiting the formation of biofilms and inhibiting a range of quorum-sensing dependent virulence factors by having an immunogenic conjugate provided as a therapeutic or prophylactic vaccine.
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