PREPARATION OF CHIRAL AMIDES AND AMINES
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United States of America Patent
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N/A
Issued Date -
N/A
app pub date -
Aug 1, 2013
filing date -
Mar 31, 2006
priority date (Note) -
Abandoned
status (Latency Note)
Importance
Abstract
This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine substructure.
First Claim
Other Claims data not available