DNA-ORIGAMI-BASED STANDARD
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United States of America Patent
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Issued Date -
Feb 27, 2014
app pub date -
Aug 21, 2013
filing date -
Aug 22, 2012
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Abstract
Arrays which utilize labeling molecules for calibrating a measuring device, such as microscopes, have a first structure based on a DNA origami as a calibration sample, wherein the DNA origami is formed into a predetermined structure by short DNA segments. The DNA origami is optionally present in an arranged manner on a support, wherein a number of short DNA segments which form the predetermined structure include a labeling molecule. Optionally, the array can have at least a second structure based on a DNA origami, different from the first structure, as a calibration sample. The array allows quantification of the labeling molecules on the basis of the number of photons per unit time.
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