SUBCUTANEOUSLY ADMINISTERED ANTI-IL-6 RECEPTOR ANTIBODY

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United States of America Patent

SERIAL NO

14061989

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Abstract

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The present application discloses methods for treating an IL-6-mediated disorder such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), systemic JIA (sJIA), polyarticular course JIA (pcJIA), systemic sclerosis, or giant cell arteritis (GCA), with subcutaneously administered antibody that binds interleukin-6 receptor (anti-IL-6R antibody). In particular, it relates to identification of a fixed dose of anti-IL-6R antibody, e.g. tocilizumab, which is safe and effective for subcutaneous administration in patients with IL-6-mediated disorders. In addition, formulations and devices useful for subcutaneous administration of an anti-IL-6R antibody are disclosed.

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Patent Owner(s)

Patent OwnerAddress
CHUGAI SEIYAKU KABUSHIKI KAISHA5-1 UKIMA 5-CHOME KITA-KU TOKYO 1158543 ?1158543

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Harari, Olivier Alfred London, GB 4 115
Terao, Kimio Funabashi City, JP 10 137
Zhang, Xiaoping Wayne, US 140 559

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