Process for Reduction and/or Removal of FXI and FXIa from Solutions Containing said Coagulation Factors
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United States of America Patent
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Issued Date -
Feb 20, 2014
app pub date -
Nov 16, 2011
filing date -
Nov 16, 2010
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Abandoned
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Abstract
A process for reduction and/or removal of FXI and FXIa from a source solution containing said coagulation factors and as main components immunoglobulins comprising the following steps:
- a) contacting the FXI and/or FXIa containing solution with an affinity chromatographic gel wherein heparin or heparan is linked to the matrix material;b) allowing adsorption of FXI and/or FXIa andc) separation of the liquid deprived of FXI and/or FXIa from the adsorption media.
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