In-Process Control for the Manufacture of Glatiramer Acetate
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United States of America Patent
Stats
-
N/A
Issued Date -
Feb 20, 2014
app pub date -
Oct 28, 2013
filing date -
Sep 7, 2011
priority date (Note) -
Abandoned
status (Latency Note)
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Importance

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Abstract
The present disclosure provides methods for manufacturing or producing glatiramer acetate having a Mp of 5000-9000 Da. These methods include: polymerizing N-carboxy anhydrides of L-alanine, benzyl-protected L-glutamic acid, trifluoroacetic acid (TFA)-protected L-lysine, and L-tyrosine to generate a sample comprising intermediate-1; treating the sample comprising intermediate-1 to partially depolymerize the protected copolymer and deprotect benzyl-protected L-glutamic acid, measuring the viscosity of the sample comprising intermediate-1 during the treatment, and ending the treatment when the viscosity of the sample is within an endpoint range, thereby generating a sample comprising intermediate-2; treating the sample comprising intermediate-2 to deprotect TFA-protected L-lysine, thereby generating intermediate-3; further processing the intermediate-3 to generate a sample glatiramer acetate; and purifying the glatiramer acetate to generate a composition comprising purified glatiramer acetate having a Mp of 5000-9000 Da.
First Claim
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Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
MOMENTA PHARMACEUTICALS INC | 1125 TRENTON-HARBOURTON ROAD TITUSVILLE NJ 08560 |
International Classification(s)

- 2013 Application Filing Year
- C07K Class
- 3861 Applications Filed
- 3209 Patents Issued To-Date
- 83.12 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Iyer, Mani S | Cambridge, US | 4 | 8 |
# of filed Patents : 4 Total Citations : 8 | |||
Kaminski, Harper | Somerville, US | 2 | 0 |
# of filed Patents : 2 Total Citations : 0 |
Cited Art Landscape
- No Cited Art to Display

Patent Citation Ranking
- 0 Citation Count
- C07K Class
- 0 % this patent is cited more than
- 11 Age
Forward Cite Landscape
- No Forward Cites to Display

Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
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11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Aug 20, 2025 |
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Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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