In-Process Control for the Manufacture of Glatiramer Acetate

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20140051830A1
SERIAL NO

14065053

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present disclosure provides methods for manufacturing or producing glatiramer acetate having a Mp of 5000-9000 Da. These methods include: polymerizing N-carboxy anhydrides of L-alanine, benzyl-protected L-glutamic acid, trifluoroacetic acid (TFA)-protected L-lysine, and L-tyrosine to generate a sample comprising intermediate-1; treating the sample comprising intermediate-1 to partially depolymerize the protected copolymer and deprotect benzyl-protected L-glutamic acid, measuring the viscosity of the sample comprising intermediate-1 during the treatment, and ending the treatment when the viscosity of the sample is within an endpoint range, thereby generating a sample comprising intermediate-2; treating the sample comprising intermediate-2 to deprotect TFA-protected L-lysine, thereby generating intermediate-3; further processing the intermediate-3 to generate a sample glatiramer acetate; and purifying the glatiramer acetate to generate a composition comprising purified glatiramer acetate having a Mp of 5000-9000 Da.

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Patent Owner(s)

Patent OwnerAddress
MOMENTA PHARMACEUTICALS INC1125 TRENTON-HARBOURTON ROAD TITUSVILLE NJ 08560

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  • 2013 Application Filing Year
  • C07K Class
  • 3861 Applications Filed
  • 3209 Patents Issued To-Date
  • 83.12 % Issued To-Date

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Iyer, Mani S Cambridge, US 4 8
Kaminski, Harper Somerville, US 2 0

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