Drug delivery systems comprising solid solutions of weakly basic drugs
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United States of America Patent
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Dec 15, 2020
Grant Date -
Feb 20, 2014
app pub date -
Jun 6, 2013
filing date -
Aug 31, 2006
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Abstract
The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 μg/mL at pH 6.8.
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