COMPOSITIONS AND METHODS FOR IDENTIFYING VIRULENCE FACTORS AND ANTI-FUNGAL AGENTS

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United States of America Patent

SERIAL NO

14003349

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Abstract

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The present invention is based on the discovery of a two- or three-organism model system that can be used to identify virulence factors involved in fungal infection and to screen for agents that attenuate the activity of those factors. The system includes a model eukaryote, the nematode, Caenorhabditis elegans, and one or more species of Candida, a fungal pathogen that infects humans, e.g., Candida albicans, C. dubliniensis, C. krusei, C. tropicalis, C. parapsilosis, or C. glabrata. The system also includes a food source for the C. elegans; the food source can be a live or attenuated bacterium, e.g., Escherichia coli.

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Patent Owner(s)

Patent OwnerAddress
WORCESTER POLYTECHNIC INSTITUTE100 INSTITUTE ROAD WORCESTER MA 01609

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Rao, Reeta Prusty Newton, US 5 6

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