CHOLESTEROL-DEPENDENT CYTOLYSIN VARIANT AND USE THEREOF IN DDS
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United States of America Patent
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app pub date -
Sep 6, 2013
filing date -
Mar 9, 2011
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Abandoned
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Abstract
The present invention provides a carrier capable of delivering a medical agent capsule encapsulating a medical agent to various target cells and tissues to cause the medical agent to be taken therein in an efficient and highly safe manner, and a drug delivery system using the carrier. The carrier has a cell or tissue specific antibody bound to an antibody binding domain of a cholesterol-dependent cytolysin variant of the present invention. The carrier can also have bound thereto, as a transport material, a functional cell or a cholesterol-containing microcapsule filled with a medicinal ingredient or a bioactive substance via domain 4 of the variant.
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