METHOD FOR RAPID PREPARATION OF SUITABLE [18F]FLUORIDE FOR NUCLEOPHILIC [18F]FLUORINATION
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United States of America Patent
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Issued Date -
Feb 6, 2014
app pub date -
Sep 6, 2011
filing date -
Sep 9, 2010
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Abandoned
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Abstract
The invention generally relates to the preparation of 18F-labeled radiopharmaceuticals. In particular, this invention relates to the advanced processes for an efficient eiution of [18F]fluoride trapped in a cartridge filled with quaternary ammonium polymer which comprises inert non-basic and non-nucleophilic counter anions. The said methods and polymer cartridges allow the rapid preparation of suitable [18F]fluoride solution, which is also less basic to reduce the formation of byproducts, finally to increase radiochemical yield and purity of 18F-radiopharmaceuticals.
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