SORTASE-MEDIATED MODIFICATION OF VIRAL SURFACE PROTEINS
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United States of America Patent
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Issued Date -
Jan 30, 2014
app pub date -
Jun 14, 2013
filing date -
Jun 14, 2012
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Abandoned
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Abstract
The present invention, in some aspects, provides methods, reagents, and kits for the functionalization of proteins on the surface of viral particles, for example, of bacteriophages, using sortase-mediated transpeptidation reactions. Some aspects of this invention provide methods for the conjugation of an agent, for example, a detectable label, a binding agent, a click-chemistry handle, or a small molecule to a surface protein of a viral particle. Kits comprising reagents useful for the generation of functionalized viral particles are also provided, as are precursor proteins that comprise a sortase recognition motif, and viral particles comprising such precursor proteins. Nucleic acids encoding viral proteins comprising a sortase recognition motif and expression vectors comprising such nucleic acids are also provided.
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