AMIS/UREI UREA-CHANNEL SUPERFAMILY CRYSTAL STRUCTURES
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United States of America Patent
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Issued Date -
Jan 16, 2014
app pub date -
Apr 23, 2013
filing date -
Apr 24, 2012
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Abstract
Embodiments of the inventions provide crystals of AmiS/Urel superfamily, urea-channel protein, methods of crystallizing such protein, and crystalline structures of such protein obtained by x-ray diffraction. Embodiments of the invention provide methods of identifying or designing antagonists and/or agonists of AmiS/Urel-superfamily, urea-channel protein based on crystalline structures thereof. In certain embodiments of the invention, the AmiS/Urel-superfamily, urea-channel protein is the Helicobacter pylori protein, HpUreI.
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