IMPLANT FOR THE CONTROLLED RELEASE OF PHARMACEUTICALLY ACTIVE AGENTS

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20140005199A1
SERIAL NO

13989346

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A pharmaceutical composition or dosage form is described for the delivery of at least one pharmaceutically active agent or drug in a sustained and controlled manner. The pharmaceutical composition is an injectable formulation which is capable of responding to local stimuli at the site of injection, such as pH and temperature, and comprises a thermoresponsive polymer composition with a suspension of pH responsive micro- or nano-particles which contain the at least one pharmaceutically active agent or drug. The thermoresponsive polymer composition is formed from poly(methyl vinyl ether) (PMVE), and an inorganic salt, and the micro- or nano-particles are formed from chitosan and eudragit. The composition can be used to treat any disease or condition which results in a decrease in pH, such as for treating a solid tumour, gout, acidosis, ketosis and the like.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF THE WITWATERSRAND JOHANNESBURGJOHANNESBURG SOUTH AFRICA JOHANNESBURG GAUTENG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Choonara, Yahya Essop Johannesburg, ZA 25 170
Claire, Du Toit Lisa Johnnesburg, ZA 1 1
Pillay, Viness Johannesburg, ZA 36 310
Wadee, Ameena Johannesburg, ZA 1 1

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