REVERSIBLY WATER-SOLUBLE NANOCRYSTALS

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United States of America Patent

APP PUB NO 20140004562A1
SERIAL NO

13878358

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Abstract

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A general, facile, and reversible nanocrystal (NCs) phase transfer protocol via ligand exchange using nucleotides and/or nucleosides is provided to generate reversibly water-soluble nanocrystals. This phase transfer strategy can be employed on a wide variety of chemically synthesized nanostructured materials including semiconductors, metal oxides and noble metals with different sizes and shapes. The nucleotide/nucleoside-capped nanocrystals can disperse homogeneously in aqueous or alcohol media retaining, for example, high photoluminescence quantum yields. The disclosed water-soluble nanocrystals have excellent colloidal and photoluminescent stability independent on the pH and ionic strength, minimal hydrodynamic size, and are stable in cells and suitable for in vitro cell labeling, cell tracking, and other bioimaging applications.

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EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY200237 NO 130 MEILONG ROAD SHANGHAI XUHUI DISTRICT SHANGHAI CITY SHANGHAI CITY 200237

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  • 2012 Application Filing Year
  • G01N Class
  • 8064 Applications Filed
  • 6361 Patents Issued To-Date
  • 78.89 % Issued To-Date
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Inventor Name Address # of filed Patents Total Citations
Liu, Lu Shanghai, CN 332 1323
Zhong, Xinhua Shanghai, CN 5 132

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  • 1 Citation Count
  • G01N Class
  • 13.80 % this patent is cited more than
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