METHODS AND COMPOSITIONS FOR PROGNOSING AND/OR DETECTING AGE-RELATED MACULAR DEGENERATION
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United States of America Patent
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Issued Date -
Jan 2, 2014
app pub date -
Sep 23, 2011
filing date -
Sep 24, 2010
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Abstract
The invention is based, in part, upon the discovery of single nucleotide polymorphisms (SNPs) and haplotypes located in promoter and intronic sequences (e.g., intron 2) of the roundabout, axon guidance receptor, homolog 1 (ROBO1) gene that are significantly associated with age-related macular degeneration (AMD) risk. The invention relates to methods and compositions for determining whether an individual is at risk of developing age-related macular degeneration by detecting whether the individual has a protective or risk variant of the ROBO1 gene.
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