ALK1 RECEPTOR AND LIGAND ANTAGONISTS AND USES THEREOF

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United States of America Patent

APP PUB NO 20130344067A1
SERIAL NO

13907798

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and antibodies that inhibit receptor-ligand interaction.

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Patent Owner(s)

Patent OwnerAddress
ACCELERON PHARMA INC128 SIDNEY STREET CAMBRIDGE MA 02139

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Grinberg, Asya Lexington, US 126 552
Knopf, John Carlisle, US 127 2555
Kumar, Ravindra Acton, US 261 3174
Pearsall, Robert S North Reading, US 15 48
Seehra, Jasbir Lexington, US 147 4048

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