Multimeric VLA-4 Antagonists Comprising Polymers Moieties

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United States of America Patent

APP PUB NO 20130338164A1
SERIAL NO

13831625

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Disclosed are conjugates which bind VLA-4. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such conjugates are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The conjugates can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

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ELAN PHARMACEUTICALS INCCALIFORNIA USA

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Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2013201420152016201720182019202020212022202320240255075100

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Inventor Name Address # of filed Patents Total Citations
Konradi, Andrei W Burlingame, US 101 764
Pleiss, Michael A Sunnyvale, US 124 945
Semko, Christopher M Fremont, US 40 332
Smith, Jenifer L San Francisco, US 15 163
Yednock, Theodore Forest Knolls, US 28 673

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