Bioinformatic processes for determination of peptide binding
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United States of America Patent
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Jul 7, 2020
Grant Date -
Dec 12, 2013
app pub date -
Mar 21, 2011
filing date -
Mar 23, 2010
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Abstract
This invention relates to processes for identifying peptide and polypeptide ligands for a binding partner by using principal component analysis of amino acids to derive vectors describing amino acid subsets corresponding to peptides with known binding affinities and then using this information in a neural network modeling process to derive binding prediction equations. These binding prediction equations are then used in the analysis of subsets of amino acids from a target source to identify peptides or polypeptides ligands in the target source that have affinity for a binding partner.
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