METHOD OF DETECTING RESISTANCE TO CANCER THERAPY

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United States of America Patent

APP PUB NO 20130324533A1
SERIAL NO

13993745

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Abstract

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We describe a polymorphic variant of a BIM {BCL2L11) gene which comprises, in 5′ to 3′ order, the nucleotide sequence set out in SEQ ID NO: 5 followed immediately by the nucleotide sequence set out in SEQ ID NO: 7. The BIM polymorphic variant may be characterised by lacking the nucleotide sequence set out in SEQ ID NO: 6. It may be used to detect BCR-ABL-independent TKI-resistance (resistance to treatment with tyrosine kinase inhibitors) for chronic myelogenous leukaemia, c-KIT/PDGFR-independent TKI-resistance for gastrointestinal stromal tumours (GIST), EGFR-independent TKI-resistance for non-small cell lung cancer (NSCLC) or JAK2-independent TKI-resistance for a myeloproliferative disorder, in an individual comprising such a polymorphism.

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Patent Owner(s)

Patent OwnerAddress
NATIONAL UNIVERSITY OF SINGAPORESINGAPORE SINGAPORE SINGAPORE CITY SINGAPORE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chuah, Charles Thuan Heng Singapore, SG 1 1
Hillmer, Axel Maximilian Singapore, SG 1 1
Juan, Wen Chun Singapore, SG 1 1
Ng, King-Pan Singapore, SG 1 1
Ong, Sin Tiong Singapore, SG 1 1
Ruan, Yijun Singapore, SG 21 115

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