Human Endogenous Retrovirus Polypeptide Compositions and Methods of Use Thereof
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United States of America Patent
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Issued Date -
Dec 5, 2013
app pub date -
May 10, 2013
filing date -
Jul 21, 2006
priority date (Note) -
Abandoned
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Abstract
The present invention provides isolated HERV polypeptides; and compositions, including immunogenic compositions, comprising a HERV polypeptide. The present invention provides immunogenic compositions comprising a nucleic acid comprising a nucleotide sequence encoding a HERV polypeptide. The immunogenic compositions are useful for stimulating a T cell immune response to a lentiviral peptide. The present invention further provides methods of stimulating an immune response in an individual to a retrovirus- or lentivirus-infected cell. The present invention further provides methods of treating cancers in which HERV polypeptides are expressed. Also provided are methods of treating disorders, involving decreasing an immune response to a HERV polypeptide.
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