NOVEL PROCESSES FOR PREPARING TRIAZOLO[4, 5-d]PYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF

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United States of America Patent

APP PUB NO 20130317220A1
SERIAL NO

13996100

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Abstract

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Provided herein is a novel process for the preparation of triazolo[4,5-d]pyrimidine derivatives. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of highly pure ticagrelor or a pharmaceutically acceptable salt thereof. Provided further herein is a novel process for the preparation of substituted cyclopentanamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a ticagrelor intermediate, 2-[[(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]-dioxol-4-yl]oxy]-1-ethanol.

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Patent Owner(s)

Patent OwnerAddress
ACTAVIS GROUP PTC EHFREYKJAVIKURVEGI 76-78 HAFNARFJORDUR 220

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Khile, Anil Shahaji Mumbai, IN 13 28
Nair, Vignesh Kerala, IN 5 5
Pradhan, Nitin Sharadchandra Maharashtra, IN 63 171
Trivedi, Nikhil Maharashtra, IN 10 9

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