CELLS HAVING DISRUPTED EXPRESSION OF PROTEINS INVOLVED IN ADME AND TOXICOLOGY PROCESSES
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United States of America Patent
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Issued Date -
Nov 28, 2013
app pub date -
Dec 28, 2011
filing date -
Dec 29, 2010
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Abandoned
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Abstract
The present invention provides cells comprising disrupted expression of at least one membrane transporter, drug metabolizing enzyme, xenobiotic sensor, or cellular stress response pathway protein. Also provided are methods for assessing the effect of an agent in the cells disclosed herein relative to comparable control cells.
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