STABILITY AND POTENCY OF HEMAGGLUTININ
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United States of America Patent
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Issued Date -
Nov 28, 2013
app pub date -
Mar 15, 2013
filing date -
Apr 13, 2012
priority date (Note) -
Abandoned
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Abstract
The present invention relates to methods of improving the stability and maintaining the potency of recombinant hemagglutinin formulations, in particular, recombinant influenza hemagglutinin (rHA). In particular, Applicants have shown that the stability of rHA formulations may be significantly improved by mutating cysteine residues or by formulating with a reducing agent and sodium citrate.
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