Delivering polypeptides to phagocytes
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United States of America Patent
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Issued Date -
Nov 28, 2013
app pub date -
May 25, 2012
filing date -
May 25, 2012
priority date (Note) -
Abandoned
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Abstract
The current invention is a particle comprising an assembly of lipid-enveloped core polypeptides and transmembrane polypeptides. The transmembrane polypeptides comprise sequences that bind to phagocytes through indirect or direct binding by surface receptors. The result of transmembrane polypeptide binding is engulfment by the phagocyte to low-pH compartments. The low pH triggers a conformational change in transmembrane polypeptides whereby lipids of particles and phagocytes are fused and the contents of the particle, including a polypeptide to be delivered to the cell, are released into the phagocyte.
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