METHODS AND COMPOSITIONS FOR INHIBITION OF ATR AND FANCD2 ACTIVATION
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United States of America Patent
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Issued Date -
Nov 21, 2013
app pub date -
Dec 13, 2012
filing date -
May 18, 2012
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Abstract
This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition have the capacity to Inhibit functions of ATR and FANCD2 on DNA replication, damage checkpoint, and repair; therefore, this composition can improve the cancer sensitivity and poor prognosis to DNA-damaging therapeutics.
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