INHIBITORS OF HCV NS5A PROTEIN
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United States of America Patent
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Issued Date -
Nov 21, 2013
app pub date -
Jun 9, 2011
filing date -
Jun 9, 2010
priority date (Note) -
Abandoned
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Abstract
Antiviral compounds may be used to inhibit or reduce the activity of Hepatitis C virus (HCV), particularly HCV's NS5A protein. In these contexts, inhibition and reduction of activity of the NS5A protein refers to a lower level of the measured activity relative to a control experiment in which the cells or the subjects are not treated with the test compound. The inhibition or reduction in the measured activity is at least a 10% reduction or inhibition. The compounds and their isomeric forms and pharmaceutically acceptable salts thereof are useful in treating and preventing HCV infection alone or when used in combination with other compounds targeting viral or cellular elements or functions involved in the HCV lifecycle.
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