TETRAMERIC ALPHA-SYNUCLEIN AS BIOMARKERS
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United States of America Patent
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Issued Date -
Nov 21, 2013
app pub date -
Nov 4, 2011
filing date -
Nov 5, 2010
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Abstract
The present invention provides the surprising finding that alpha-synuclein exists in vivo as a folded tetramer. Provided are various methods and technologies that arise from this finding, including methods and kits for identifying individuals susceptible to or suffering from certain diseases, disorders or conditions associated with stability of alpha-synuclein tetramers, and/or individuals likely (or not) to respond to therapy with agents that alter level and/or stability of alpha-synuclein tetramers.
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