Modified Antibody Compositions, Methods of Making and Using Thereof
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United States of America Patent
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Issued Date -
Nov 21, 2013
app pub date -
Mar 4, 2013
filing date -
Jan 12, 2009
priority date (Note) -
Abandoned
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Abstract
The present disclosure provides modified antibodies which contain an antibody or antibody fragment (AB) modified with a masking moiety (MM). Such modified antibodies can be further coupled to a cleavable moiety (CM), resulting in activatable antibodies (AAs), wherein the CM is capable of being cleaved, reduced, photolysed, or otherwise modified. AAs can exhibit an activatable conformation such that the AB is more accessible to a target after, for example, removal of the MM by cleavage, reduction, or photolysis of the CM in the presence of an agent capable of cleaving, reducing, or photolysing the CM. The disclosure further provides methods of making and using such modified antibodies and activatable antibodies.
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