Cylodextrin Complexation Methods for Formulating Peptide Proteasome Inhibitors
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Issued Date -
Nov 14, 2013
app pub date -
Sep 13, 2012
filing date -
May 8, 2012
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Abstract
This disclosure provides methods for formulating compositions comprising one or more peptide proteasome inhibitors and a cyclodextrin, particularly a substituted cyclodextrin. Such methods substantially increase the solubility and stability of these proteasome inhibitors and facilitate both their manufacture and administration.
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