Method of Forming Cell Spheroids Cultured in Serum-Free Manner on Nanoscale Coatings of Hyaluronic Acid with High Molecular Weight
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United States of America Patent
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Nov 14, 2013
app pub date -
May 14, 2012
filing date -
May 14, 2012
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Abstract
A method of forming cell spheroids cultured in a serum-free manner on nanoscale coatings of hyaluronic acid with high molecular weight is disclosed. Corneal stromal cells are cultured on the hyaluronic acid coatings with nanotopography in the serum-free manner. Experimental results show that the cells cultured on the hyaluronic acid coatings (1.1-1.7 nm) increase cell-cell interaction, and when the cells form three-dimensional spheroids, they have higher biological synthetic capabilities and can secret more extracellular matrix, which has potential applications in corneal stromal tissue reconstruction.
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