BIOMARKER FOR AMYLOID-B-RELATED NEUROLOGICAL DISORDERS
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United States of America Patent
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Issued Date -
Nov 14, 2013
app pub date -
Dec 5, 2011
filing date -
Dec 16, 2010
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Abandoned
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Abstract
A novel biomarker for diagnosing amyloid β-related neuropathy such as Alzheimer's disease is provided. Disclosed is a method for diagnosing Alzheimer's disease comprising measuring the level of a MFG-E8 protein in a blood, serum or plasma sample obtained from a human or animal subject, wherein the measured value is used as a marker for diagnosis of Alzheimer's disease. The MFG-E8 protein is found to bind to phosphatidylserine in a Ca2+ dependent manner in a culture supernatant of mouse brain nerve cells, which are a dementia model stimulated with Aβ42. It is also found that the level of the MFG-E8 protein is increased in patients with Alzheimer's disease.
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